Abstract |
Maternal serum (MS) and amniotic fluid (AF) alpha-fetoprotein (alpha-FP) levels were serially determined in 18 cases of elective midtrimester abortion. Prostaglandin F2alpha ( PGF2alpha) and 20% NaCl were used as the abortifacients in 2 groups of 9 patients, respectively. The time from instillation to abortion (IAT) was accurately recorded in all cases. A marked 260-600% increase in MS alpha-FP occurred prior to fetal demise in both groups. Amniotic fluid alpha-FP content remained largely unchanged for the first 6 hours following intraamniotic prostaglandin injection. A 50% INCREASE WAS OBSERVED IN THE AF alpha-FP content in the group with 20% NaCl- induced abortion (after an initial dilutionary drop). The results of this investigation confirm the value of alpha-FP in MS as a marker of impending fetal demise. This rise is not caused by a prior alpha-FP change in the AF. The data suggest a major fetomaternal transplacental route for alpha-FP.
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Authors | R R Weiss, J N Macri, J Robins, K W Elligers |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 48
Issue 6
Pg. 718-22
(Dec 1976)
ISSN: 0029-7844 [Print] United States |
PMID | 63108
(Publication Type: Journal Article)
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Chemical References |
- Prostaglandins F
- alpha-Fetoproteins
- Sodium Chloride
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Topics |
- Abortion, Induced
- Adolescent
- Adult
- Amniotic Fluid
(analysis)
- Female
- Fetal Death
(diagnosis)
- Fetal Distress
(diagnosis)
- Humans
- Pregnancy
- Pregnancy Trimester, Second
- Prostaglandins F
(therapeutic use)
- Sodium Chloride
(therapeutic use)
- alpha-Fetoproteins
(analysis)
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