The effect of bis-pyridinium oximes on neuromuscular blockade induced by highly toxic organophosphates in rat.

Abstract

Two bispyridinium oximes, BDB-27 and HGG-12, were tested in vivo for their ability to restore neuromuscular function in rats poisoned by 1.3 LD50 of sarin, soman, tabun and XV, using isolated phrenic nerve-diaphragm preparation. Their effectiveness was evaluated in comparison with the two most potent oximes in this respect, HI-6 and TMB-4. It was found that BDB-27 was equal or superior to HI-6 in sarin, soman and XV and to TMB-4 in tabun poisoned animals. Recovery of function after HGG-12 was equal to HI-6 only in soman poisoning, but much less pronounced against neuromuscular blockade induced by the other three anticholinesterases. The results point at the equal effectiveness of BDB-27 in functional recovery in poisoning by all four toxic agents tested, so far not encountered by any other oxime.

• Authors: D Jovanović
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 262 Issue 2 Pg. 231-41 (Apr 1983) ISSN: 0003-9780 [Print] Belgium
• PMID: 6307195 (Publication Type: Journal Article)

Chemical References

• Antidotes
• Cholinesterase Inhibitors
• Organophosphorus Compounds
• Pyridinium Compounds
• HGG 12
• BDB 27
• Cholinesterases

Topics

• Animals
• Antidotes (pharmacology)
• Brain (drug effects, enzymology)
• Cholinesterase Inhibitors (toxicity)
• Cholinesterases (metabolism)
• Lethal Dose 50
• Male
• Neuromuscular Junction (drug effects, physiology)
• Organophosphorus Compounds (toxicity)
• Pyridinium Compounds (pharmacology)
• Rats
• Rats, Inbred Strains
• Synaptic Transmission