Calcitonin increases calcium content and glucose-6-phosphatase activity in hepatic microsomes of rats.

Abstract

The effect of calcitonin (CT) on calcium content and glucose-6-phosphatase activity in the hepatic microsomes of rats was investigated. A single sc administration of CT (80 MRC mU/100 g body weight) produced a significant increase in microsomal calcium content and a corresponding elevation of microsomal glucose-6-phosphatase activity. An appreciable effect of CT was observed at a dose of 20 MRC mU/100 g body weight. On the other hand, the removal of calcium by 10 mM EGTA washing of the microsomes caused a marked reduction of glucose-6-phosphatase activity raised by CT administration. The addition of calcium ion at the amount of 10(-2)-10(3) nmoles Ca2+ per mg protein in the microsomes produced a significant increase in glucose-6-phosphatase activity. The present results suggest that microsomal calcium increased by CT administration activates glucose-6-phosphatase in the hepatic microsomes of rats.

• Authors: M Yamaguchi, K Momose
• Journal: Acta endocrinologica (Acta Endocrinol (Copenh)) Vol. 102 Issue 4 Pg. 572-6 (Apr 1983) ISSN: 0001-5598 [Print] Denmark
• PMID: 6303033 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Egtazic Acid
• Calcitonin
• Glucose-6-Phosphatase
• Calcium

Topics

• Animals
• Calcitonin (pharmacology)
• Calcium (metabolism)
• Dose-Response Relationship, Drug
• Egtazic Acid (pharmacology)
• Glucose-6-Phosphatase (metabolism)
• Male
• Microsomes, Liver (metabolism)
• Rats
• Rats, Inbred Strains