Abstract |
The activities of the pyrrolizines, Compounds I and II, and the pyrroles, Compounds IV and V, are reported in nude mouse-grown HT-29 human adenocarcinoma of the colon, DO 1 human oat carcinoma of the lung, and CL 1 human duct cell carcinoma of the breast (coded as CX-1, LX-1, and MX-1, respectively, by the National Cancer Institute). Compounds II and IV were active against all three experimental tumors; both compounds produced significant tumor regression in the human breast tumor xenograft and Compound IV caused tumor regression in the human lung tumor xenograft.
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Authors | W K Anderson |
Journal | Cancer research
(Cancer Res)
Vol. 42
Issue 6
Pg. 2168-70
(Jun 1982)
ISSN: 0008-5472 [Print] United States |
PMID | 6280852
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adenocarcinoma
(drug therapy)
- Animals
- Breast Neoplasms
(drug therapy)
- Carcinoma, Small Cell
(drug therapy)
- Cell Line
- Colonic Neoplasms
(drug therapy)
- Drug Evaluation, Preclinical
- Humans
- Lung Neoplasms
(drug therapy)
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Neoplasms
(drug therapy)
- Neoplasms, Experimental
(drug therapy)
- Pyrroles
(therapeutic use)
- Pyrrolidines
(therapeutic use)
- Transplantation, Heterologous
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