Serum bile acids in patients with hyperlipidaemia.

Abstract

Individual serum bile acids were analysed by an improved gas liquid chromatography method in 12 patients with primary hyperlipidaemia. Total serum bile acid concentrations were raised in 10 subjects. Ursodeoxycholic acid was found in all 12 patients. It was present in significantly greater concentrations, accounted for a greater proportion of the total serum bile acids, and occurred more frequently than in patients with various forms of hepatobiliary disease. Patients with hyperlipidaemia had proportionately less deoxycholic acid than controls but more than patients with liver disease. There was proportionately less chenodeoxycholic acid in patients with hypercholesterolaemia, in whom the primary bile acid ratio was raised.

• Authors: C R Pennington, P E Ross, M C Bateson, I A Bouchier
• Journal: Journal of clinical pathology (J Clin Pathol) Vol. 31 Issue 1 Pg. 58-62 (Jan 1978) ISSN: 0021-9746 [Print] England
• PMID: 627619 (Publication Type: Journal Article)

Chemical References

• Bile Acids and Salts
• Cholic Acids
• Deoxycholic Acid
• Chenodeoxycholic Acid

Topics

• Bile Acids and Salts (blood)
• Chenodeoxycholic Acid (blood)
• Cholic Acids (blood)
• Deoxycholic Acid (analogs & derivatives, blood)
• Humans
• Hyperlipidemias (blood)
• Liver Diseases (blood)