Chronic heart failure in the guinea pig increases cardiac alpha 1- and beta-adrenoceptors.

Abstract

Compared with sham-operated guinea pigs, chronic heart failure produced by aortic constriction resulted in a 79% increase in alpha 1-adrenoceptor density as measured by [3H]prazosin binding (73 +/- 15 vs. 131 +/- 20 fmol/mg protein, P < 0.05); beta-adrenoceptor number, measured by (-)-[3H]dihydroalprenolol binding, increased by 93% (28 +/- 3.4 vs. 54 +/- 5.2 fmol/mg protein, P < 0.01). For each radioligand KD values were unchanged. Thus, congestive heart failure due to chronic pressure overload results in compensatory augmentation of alpha 1- and beta-adrenoceptor numbers.

• Authors: J S Karliner, P Barnes, M Brown, C Dollery
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 67 Issue 1 Pg. 115-8 (Oct 03 1980) ISSN: 0014-2999 [Print] Netherlands
• PMID: 6252020 (Publication Type: Journal Article)

Chemical References

• Receptors, Adrenergic
• Receptors, Adrenergic, alpha
• Receptors, Adrenergic, beta

Topics

• Animals
• Guinea Pigs
• Heart Failure (physiopathology)
• Male
• Radioligand Assay
• Receptors, Adrenergic (physiology)
• Receptors, Adrenergic, alpha (physiology)
• Receptors, Adrenergic, beta (physiology)