Abstract |
Preleukemic bone marrow and spleen cells of irradiated C57BL/6 mice that were inoculated with the radiation-induced leukemia virus variant D-RadLV differ from autonomous end-stage leukemia cells in the expression of the receptor for peanut agglutinin. As a result, the preleukemic cells are agglutinated by peanut agglutinin and the end-stage cells are not. This observation provides further evidence that preleukemic cells possess surface markers similar to those of the prothymocyte. In vitro and in vivo thymocyte-virus interactions reveal that cells susceptible to D-RadLV transformation are present mainly among the peanut agglutinin-receptor-bearing thymocyte population which has previously been demonstrated to be immunologically immature.
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Authors | Y Reisner, N Sharon, N Haran-Ghera |
Journal | Proceedings of the National Academy of Sciences of the United States of America
(Proc Natl Acad Sci U S A)
Vol. 77
Issue 4
Pg. 2244-6
(Apr 1980)
ISSN: 0027-8424 [Print] United States |
PMID | 6246529
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Lectins
- Plant Lectins
- Receptors, Drug
|
Topics |
- Animals
- Arachis
- Bone Marrow
(metabolism)
- Lectins
(metabolism)
- Leukemia Virus, Murine
- Mice
- Plant Lectins
- Preleukemia
(metabolism)
- Receptors, Drug
(metabolism)
- Spleen
(metabolism)
- Thymus Gland
(metabolism)
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