Evaluation of hematoporphyrin photoradiation therapy to treat choroidal melanomas.

Abstract

Hematoporphyrin derivative-photoradiation therapy (HPD-PRT) was used to treat choroidal melanomas in 23 human subjects. Tumor sizes were divided into three categories: less than 500 mm3 (11 patients), 500-1,000 mm3 (four patients), and greater than 1,000 mm3 (eight patients). Tumors were exposed to 630 nm laser light at total doses of 300-3,000 J/cm2. Significant tumor reduction was noted in the subjects with initial tumor volume of less than 500 mm3 and 500-1,000 mm3.

• Authors: R A Bruce Jr
• Journal: Lasers in surgery and medicine (Lasers Surg Med) Vol. 4 Issue 1 Pg. 59-64 ( 1984) ISSN: 0196-8092 [Print] United States
• PMID: 6235417 (Publication Type: Journal Article)

Chemical References

• Hematoporphyrins
• Radiation-Sensitizing Agents
• Hematoporphyrin Derivative

Topics

• Choroid Neoplasms (drug therapy, physiopathology)
• Hematoporphyrin Derivative
• Hematoporphyrins (therapeutic use)
• Humans
• Laser Therapy
• Melanoma (drug therapy, physiopathology)
• Photochemotherapy
• Radiation-Sensitizing Agents (therapeutic use)
• Visual Acuity