Effect of anthelmintic treatment on the development of resistance in sheep vaccinated or experimentally infected with Dictyocaulus filaria.

Abstract	This investigation was undertaken to study the immune response of Iraqi sheep vaccinated with Dictyocaulus filaria larvae (Filiraq) and to determine the effect of tetramisole on the development of resistance to reinfection. The findings confirm the effectiveness of Filiraq in conferring protection against experimental infection with D filaria. However, the administration of anthelmintic four weeks after each vaccination interfered with the development of immunity. Termination of D filaria infection at 28 days by tetramisole treatment also prevented the immune response.
Authors	A A Al-Saadi, S A Al-Samarrae, K I Altaif
Journal	Research in veterinary science (Res Vet Sci) Vol. 36 Issue 2 Pg. 144-6 (Mar 1984) ISSN: 0034-5288 [Print] England
PMID	6232668 (Publication Type: Journal Article)
Chemical References	Vaccines Vaccines, Attenuated Tetramisole
Topics	Animals Body Weight Combined Modality Therapy Dictyocaulus (immunology) Dictyocaulus Infections (drug therapy, immunology) Immunity (drug effects) Male Metastrongyloidea (immunology) Sheep Sheep Diseases (drug therapy, immunology) Tetramisole (pharmacology, therapeutic use) Vaccines (immunology) Vaccines, Attenuated (immunology)

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