The influence of ultraviolet B irradiation on the excretion of the main urinary metabolite of prostaglandin F1 alpha and F2 alpha in psoriatic and normal subjects.

Abstract

The influence of ultraviolet B (UVB) irradiation on the excretion of the main urinary metabolite of prostaglandin F1 alpha and F2 alpha (PGF-MUM) in 7 normal male volunteers and 7 male patients with stable psoriasis was examined. The excretion of PGF-MUM was increased during the first 24 hours after UVB irradiation of back skin and was generally reduced to near pre-irradiation levels during the next 24 hours after irradiation, in both normal and psoriatic subjects. Although pre-irradiation levels of PGF-MUM excretion in psoriatic patients were lower than those in normal subjects as previously reported, it was demonstrated that PGF-MUM excretion after UVB irradiation in psoriatic patients was fairly increased and amounted to near the mean pre-irradiation level in normal subjects. These results suggested not only a disorder in endogenous prostaglandin synthesis in psoriatic patients but a considerable capacity of psoriatic skin to synthesize prostaglandin after UVB irradiation.

• Authors: H Katayama, H Hori
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 64 Issue 1 Pg. 1-4 ( 1984) ISSN: 0001-5555 [Print] Sweden
• PMID: 6203274 (Publication Type: Journal Article)

Chemical References

• Fatty Acids
• Prostaglandins F
• Prostanoic Acids
• prostaglandin F-main urinary metabolite

Topics

• Adult
• Aged
• Fatty Acids (urine)
• Humans
• Male
• Middle Aged
• Prostaglandins F
• Prostanoic Acids (urine)
• Psoriasis (radiotherapy, urine)
• Ultraviolet Therapy