Functional diversity within the suppressor phenotype as defined by monoclonal antibody in T-cell prolymphocytic leukemia.

Abstract

A patient with T-cell prolymphocytic leukemia (T-PLL) is described. The malignant T-cells from the patient were predominantly Leu-2-positive, indicating a suppressor phenotype. The cells were then tested to determine their functional capabilities. The patient's Leu-2-positive cells initially suppressed B-cell proliferation, as predicted by their phenotype but later functioned as T helper cells in the pokeweed mitogen system without a change in phenotype. The cells also responded inadequately to alloantigen and mitogen despite addition of exogenous T-cell growth factor (TCGF). Leu-2-positive prolymphocytes from the spleen of the patient were constitutive producers of TCGF. Surface phenotype using monoclonal antibody was inadequate to predict T-cell function of the cells from this patient with T-PLL. In addition, these data suggest there may be functional subpopulations within the OKT8+ phenotype. Constitutive TCGF production by malignant post-thymic T-cells may represent a mechanism by which these cells sustain their own growth.

• Authors: K W Zamkoff, B J Poiesz, F W Ruscetti, J L Moore, F R Davey, A T Planas, H Lamberson
• Journal: American journal of hematology (Am J Hematol) Vol. 16 Issue 4 Pg. 409-17 (May 1984) ISSN: 0361-8609 [Print] United States
• PMID: 6202139 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Monoclonal
• Interleukin-2
• Interferons

Topics

• Antibodies, Monoclonal (immunology)
• Antibody Diversity
• Antibody Formation
• Genetic Variation
• Humans
• Interferons (biosynthesis)
• Interleukin-2 (biosynthesis)
• Leukemia, Lymphoid (genetics, immunology)
• Lymphocyte Activation
• Male
• Middle Aged
• Phenotype
• T-Lymphocytes (classification, immunology)
• T-Lymphocytes, Helper-Inducer (immunology)
• T-Lymphocytes, Regulatory (immunology)