Degradation of rRNA in interferon-treated vaccinia virus-infected cells.

Abstract

In interferon-treated mouse L cells, following infection with a DNA-containing virus, vaccinia, synthesis of unique 2'-5'-linked oligonucleotides of the general formula ppp5'A2'(p5'A)n, abbreviated as 2-5A, was detected by competition radiobinding assay. In addition, degradation of rRNA into discrete and characteristic products, similar to those produced by 2-5A-activated endonuclease, was observed. The degradation of rRNA may represent a significant component of antiviral action of interferon in vaccinia virus-infected cells.

• Authors: B B Goswami, O K Sharma
• Journal: The Journal of biological chemistry (J Biol Chem) Vol. 259 Issue 3 Pg. 1371-4 (Feb 10 1984) ISSN: 0021-9258 [Print] United States
• PMID: 6198324 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adenine Nucleotides
• Oligoribonucleotides
• RNA, Ribosomal
• 2',5'-oligoadenylate
• Interferons

Topics

• Adenine Nucleotides (metabolism)
• Animals
• Interferons (pharmacology)
• Kinetics
• L Cells (metabolism)
• Mice
• Oligoribonucleotides (metabolism)
• Protein Biosynthesis (drug effects)
• RNA, Ribosomal (metabolism)
• Vaccinia virus (drug effects, genetics)