Abstract |
Liver alterations occurring after 1, 6 or 10 days of treatment with the hepatocarcinogen beta-blocker DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butyl-amino-propan-2-ol ( ZAMI 1305) were studied in male and female Wistar rats. In agreement with its sex-dependent oncogenicity, ZAMI 1305 administration causes DNA damage in the liver of the female but not of the male rat, with the only exception of 2 out of 4 males treated for 6 days. In female rat, the amount of DNA damage increases from 1 to 6 days of treatment, being unchanged at 10 days; a small portion of DNA is however damaged. ZAMI 1305 administration to female rat induces also: (i) an increase of the relative liver weight, of the DNA and RNA synthesizing activity; (ii) a decrease of the number of hepatocytes in mitosis; (iii) a minimal oval cell hyperplasia. When the same parameters were studied in ZAMI 1305-treated male rats, they were unaffected or changed to a less extent in respect to female rats.
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Authors | M Presta, C Mazzocchi, S Ziliani, T Zavanella, G Ragnotti |
Journal | Chemico-biological interactions
(Chem Biol Interact)
Vol. 52
Issue 2
Pg. 203-12
(Dec 1984)
ISSN: 0009-2797 [Print] Ireland |
PMID | 6150768
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Antagonists
- Carcinogens
- Propanolamines
- ZAMI 1305
- Aspartate Aminotransferases
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Topics |
- Adrenergic beta-Antagonists
(pharmacology)
- Animals
- Aspartate Aminotransferases
(blood)
- Carcinogens
- Cell Nucleus
(drug effects, metabolism)
- DNA Replication
(drug effects)
- Female
- Liver
(drug effects, metabolism, pathology)
- Male
- Propanolamines
(pharmacology)
- Rats
- Rats, Inbred Strains
- Sex Factors
- Transcription, Genetic
(drug effects)
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