Acute and subchronic effects of bometolol on blood pressure in hypertensive rats.

Abstract

Bometolol is a cardiospecific beta-adrenergic blocking drug. The effect on blood pressure was determined in hypertensive rats in acute and subchronic experiments. In acute experiment bometolol, 10-30 mg/kg, p.o., was given to spontaneously hypertensive rats; deoxycorticosterone and salt hypertensive rats; and two kidney, one clip hypertensive rats. Blood pressure was determined continuously for 8 h and after 24 h in unanesthetized condition. The blood pressure lowered by bometolol was dose-dependent in three types of hypertension. In subchronic experiment, bometolol at a dose of 10-30 mg/kg or 100-300 mg/kg, p.o., were given for 5 weeks to deoxycorticosterone and salt hypertensive rats; and two kidney, one clip hypertensive rats. Bometolol did not show antihypertensive effect in either type of hypertension, although bometolol decreased heart rate dose-dependently. Bometolol treatment at the above doses decreased plasma renin activity, heart and kidney weights, and incidence of vascular lesion in either hypertensive rat. Toxic symptom was seen 3 days after bometolol treatment of 300 mg/kg in deoxycorticosterone and salt hypertensive rats.

• Authors: T X Watanabe, Y Watanabe, Y Hasegawa, Y Kudo, K Kawashima, H Sokabe
• Journal: Journal of pharmacobio-dynamics (J Pharmacobiodyn) Vol. 4 Issue 7 Pg. 505-12 (Jul 1981) ISSN: 0386-846X [Print] Japan
• PMID: 6117612 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Propanolamines
• bometolol

Topics

• Adrenergic beta-Antagonists (adverse effects, pharmacology, therapeutic use)
• Animals
• Blood Pressure (drug effects)
• Depression, Chemical
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Heart Rate (drug effects)
• Hypertension (drug therapy)
• Propanolamines (adverse effects, pharmacology, therapeutic use)
• Rats