Sex steroids in women with liver cirrhosis.

Abstract

Eighteen women with hepatic cirrhosis were examined for plasma levels of testosterone, estrone, estradiol, progesterone and sex hormone binding globulin. For eight who were amenorrheic, with advanced liver cirrhosis and ascites, the reduction of testosterone and rise in estrone and sex hormone binding globulin concentrations were significant. Plasma extradiol and progesterone were lower than normal levels, but the differences were not statistically significant. The other ten patients were menstruating (mostly irregularly), and their hormonal levels were assessed in different states of their cycles. All of them did not ovulate, had low levels of plasma progesterone and also showed consistent estrone concentration excess relative to estradiol and significant lowering of testosterone and elevation of sex hormone binding globulin. These findings are compared with previous reports on males with liver cirrhosis.

• Authors: M M Shaaban, S A Ghaneimah, W A Hammad, M M El-Sharkawy, S I Elwan, Y A Ahmed
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 18 Issue 3 Pg. 181-4 ( 1980) ISSN: 0020-7292 [Print] United States
• PMID: 6109650 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Gonadal Steroid Hormones
• Sex Hormone-Binding Globulin
• Estrone
• Testosterone
• Progesterone
• Estradiol

Topics

• Adolescent
• Adult
• Amenorrhea (blood, complications)
• Estradiol
• Estrone (blood)
• Female
• Gonadal Steroid Hormones (blood)
• Humans
• Liver Cirrhosis (blood, complications)
• Middle Aged
• Progesterone (blood)
• Sex Hormone-Binding Globulin (analysis)
• Testosterone (blood)