In vitro and in vivo activities of ketoconazole and itraconazole against Pityrosporum orbiculare.

Abstract

The MICs of ketoconazole and itraconazole against Pityrosporum orbiculare were 0.02 to 0.05 and 0.1 to 0.2 micrograms ml-1, respectively. In a rabbit model, orally administered ketoconazole (1 mg kg-1) afforded protection against experimental pityriasis (tinea) versicolor in all animals. Itraconazole (5 mg kg-1) was effective in four of five rabbits.

• Authors: J Faergemann
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 26 Issue 5 Pg. 773-4 (Nov 1984) ISSN: 0066-4804 [Print] United States
• PMID: 6097177 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antifungal Agents
• Itraconazole
• Ketoconazole

Topics

• Animals
• Antifungal Agents (pharmacology, therapeutic use)
• Itraconazole
• Ketoconazole (analogs & derivatives, pharmacology, therapeutic use)
• Malassezia (drug effects)
• Male
• Microbial Sensitivity Tests
• Rabbits
• Tinea Versicolor (drug therapy)