Abstract |
Fourteen patients with an average of more than 60 episodes of upper airway obstruction during night sleep were treated with a nonsedating tricyclic antidepressant, protriptyline. Frequency and duration of recorded apneas decreased in 11 cases, and satisfactory control of sleep apnea was maintained with medical therapy alone in 8 of these 11 patients for 7 to 15 months. Potential adverse effects of protriptyline, particularly on the cardiovascular system, limit its use in this illness. These results indicate the possibility of pharmacologic reversal of sleep-induced incoordination of the upper airway.
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Authors | R W Clark, H S Schmidt, S F Schaal, H Boudoulas, D E Schuller |
Journal | Neurology
(Neurology)
Vol. 29
Issue 9 Pt 1
Pg. 1287-92
(Sep 1979)
ISSN: 0028-3878 [Print] United States |
PMID | 573409
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Dibenzocycloheptenes
- Protriptyline
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Topics |
- Adult
- Aged
- Airway Obstruction
(drug therapy)
- Apnea
(drug therapy)
- Dibenzocycloheptenes
(therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Protriptyline
(therapeutic use)
- Sleep Wake Disorders
(drug therapy)
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