Canine cyclic neutropenia: Erythropoietin and platelet cycles after bone marrow transplantation.

Abstract

The marrow of a dog affected with cyclic neutropenia (CN) was transplanted into an unaffected supralethally irradiated litermate. Prompt engraftment occurred, and cyclic rises and falls in numbers of platelets, reticulocytes, and granulocytes were noted in the recipient soon after engraftment. Prior to transplantation and under hypoxic conditions, the donor had serum erythropoietin (ESF) peak levels at 11-12-day intervals. Following transplatation and under hypoxic conditions, cyclic peaks of ESF occurred in the transplanted dog.

• Authors: J B Jones, R D Lange, T J Yang, H Vodopick, E S Jones
• Journal: Blood (Blood) Vol. 45 Issue 2 Pg. 213-9 (Feb 1975) ISSN: 0006-4971 [Print] United States
• PMID: 47249 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Drug Combinations
• Iron Radioisotopes
• Polymyxins
• Erythropoietin
• Ampicillin
• Iron
• Dihydrostreptomycin Sulfate
• Methotrexate

Topics

• Agranulocytosis (veterinary)
• Ampicillin (therapeutic use)
• Animals
• Biological Assay
• Blood Platelets
• Bone Marrow Cells
• Bone Marrow Transplantation
• Dihydrostreptomycin Sulfate (therapeutic use)
• Dog Diseases (blood)
• Dogs
• Drug Combinations
• Erythrocytes (metabolism)
• Erythropoietin (analysis)
• Hypoxia (blood)
• Iron (blood)
• Iron Radioisotopes
• Leukocyte Count
• Methotrexate (therapeutic use)
• Neutropenia (veterinary)
• Periodicity
• Polymyxins (therapeutic use)
• Radiation Chimera
• Reticulocytes
• Transplantation, Homologous