Previous studies have shown that a single injection of
endotoxin inhibits renal cortical fibrinolytic activity in the rabbit. This suggests that the initial injection of
endotoxin may prepare for the generalized
Shwartzman reaction by depletion of cortical fibrinolytic activity. A
fibrin slide technic was used to determine whether
Thorotrast(R) and
cortisone prepare for the generalized
Schwartzman reaction by a similar mechanism. Renal cortical fibrinolytic activity was inhibited following
Thorotrast injection, but no inhibition could be detected following
cortisone injection. This suggests that
Thorotrast, like
endotoxin, prepares for the generalized
Shwartzman reaction by depletion of cortical fibrinolytic activity. Failure to demonstrate inhibition of lytic activity following
cortisone injection may indicate that
cortisone prepares for the generalized
Shwartzman reaction by another mechanism, or that the
fibrin slide technic was unable to detect quantitative changes in lytic activity.