Comparison of therapeutic routes in experimental Pseudomonas keratitis.

Abstract	We determined the efficacy of tobramycin administered by topical, intramuscular, and subconjunctival routes in guinea pigs and rabbits with experimental Pseudomonas keratitis. The topical route of administration was consistently more effective than either subconjunctival or intramuscular routes. Subconjunctival injection of antibiotic did not enhance the effectiveness of topical therapy in either guinea pigs or rabbits. Intramuscular tobramycin was more effective than saline in guinea pigs with keratitis but not in rabbits with keratitis.
Authors	S D Davis, L D Sarff, R A Hyndiuk
Journal	American journal of ophthalmology (Am J Ophthalmol) Vol. 87 Issue 5 Pg. 710-6 (May 1979) ISSN: 0002-9394 [Print] United States
PMID	443343 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Anti-Bacterial Agents Tobramycin
Topics	Administration, Topical Animals Anti-Bacterial Agents (therapeutic use) Disease Models, Animal Guinea Pigs Humans Injections Injections, Intramuscular Keratitis (drug therapy) Kinetics Pseudomonas Infections (drug therapy) Rabbits Tobramycin (pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!