Response of two strains of L5178Y cells to cis-dichlorobis(cyclopentylamine)platinum(II). II. Differential effects of caffeine.

Abstract

Two strains of L5178Y murine lymphoma, inversely cross-sensitive to X-rays and UV light, were shown previously to respond to treatment with an antitumour platinum complex, cis-dichlorobis(cyclopentylamine)-platinum(II) (cis-PAD), in a similar manner as to UV. Enhancement of chromosomal damage and potentiation of lethal effect of cis-PAD by 0.75 mM caffeine were found in cis-PAD and UV light-resistant L5178Y-S strain but not in cis-PAD and UV light-sensitive L5178Y-R strain. These results suggest that the extreme sensitivity of L5178Y-R strain to cis-PAD and UV light is caused to some extent by deficiency in a caffeine-sensitive post-replication repair system.

• Authors: I Szumiel
• Journal: Chemico-biological interactions (Chem Biol Interact) Vol. 24 Issue 1 Pg. 73-82 (Jan 1979) ISSN: 0009-2797 [Print] Ireland
• PMID: 428003 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Caffeine
• Cisplatin

Topics

• Animals
• Caffeine (pharmacology)
• Cell Survival (drug effects)
• Chromosome Aberrations
• Cisplatin (pharmacology)
• Drug Interactions
• L Cells (drug effects)
• Mice