Production of pancreatic acinar cell carcinoma by combined administration of 4-hydroxyaminoquinoline 1-oxide and azaserine in partial pancreatectomized rats.

Abstract

The effect of azaserine on the pancreatic tumorigenesis of 4-hydroxyaminoquinoline 1-oxide (4-HAQO) after partial pancreatectomy in rats was studied. Pancreatic acinar cell carcinomas were produced in 7 out of 10 rats (70%), which received 7 mg/kg body wt. 4-HAQO 3 days after partial pancreatectomy, followed by 10 weekly injections of 30 mg/kg body wt. azaserine. Partial pancreatectomy enhanced the carcinogenesis of 4-HAQO, which was further promoted by azaserine.

• Authors: Y Konish, A Denda, S Inui, S Takahashi, N Ueda, M Namiki
• Journal: Cancer letters (Cancer Lett) Vol. 4 Issue 4 Pg. 229-34 (Apr 1978) ISSN: 0304-3835 [Print] Ireland
• PMID: 417803 (Publication Type: Journal Article)

Chemical References

• Aminoquinolines
• 4-Hydroxyaminoquinoline-1-oxide
• Azaserine

Topics

• 4-Hydroxyaminoquinoline-1-oxide (toxicity)
• Aminoquinolines (toxicity)
• Animals
• Azaserine (toxicity)
• Carcinoma (chemically induced, pathology)
• Drug Synergism
• Male
• Neoplasms, Experimental (chemically induced)
• Pancreas (physiology)
• Pancreatectomy
• Pancreatic Neoplasms (chemically induced, pathology)
• Rats
• Regeneration