Abstract |
A 47-year-old male patient with tuberous xanthomas, xanthochromia striata palmaris, hypercholesterolemia, hypertriglyceridemia, chylomicronemia and a "broad-beta" band on agarose gel electrophoresis is the subject of this report. The classification of the metabolic disturbances as hyperlipoproteinemia, type III, with apo E-3 deficiency was derived from the results obtained by isoelectric focusing and density gradient ultracentrifugation. Since June 1983, the patient has been successfully treated with probucol ( Lurselle) with no complementary diet. The serum cholesterol concentration was reduced by a maximum of 45%, together with clear regression of the xanthochromia striata palmaris and beginning xanthoma regression. The HDL cholesterol level did not climb again, and there were no side effects as a result of the probucol therapy.
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Authors | R Engst |
Journal | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
(Hautarzt)
Vol. 36
Issue 11
Pg. 629-34
(Nov 1985)
ISSN: 0017-8470 [Print] Germany |
Vernacular Title | Hyperlipoproteinämie Typ III mit Apolipoprotein E-Phänotyp 2/2. |
PMID | 4077508
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Apolipoproteins E
- Cholesterol, HDL
- Chylomicrons
- Triglycerides
- Uric Acid
- Cholesterol
- Probucol
|
Topics |
- Apolipoproteins E
(blood, genetics)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Chylomicrons
(blood)
- Humans
- Hyperlipoproteinemia Type III
(blood, drug therapy, genetics)
- Male
- Middle Aged
- Phenotype
- Probucol
(therapeutic use)
- Triglycerides
(blood)
- Uric Acid
(blood)
- Xanthomatosis
(blood, drug therapy, genetics)
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