[Clinical evaluation of a new parenteral penicillin, aspoxicillin, in children].

Abstract

Aspoxicillin (ASPC) was evaluated for its efficacy and safety in 30 infants and children with acute bacterial infections. The disease categories included acute respiratory tract (22), soft tissue (3), urinary tract (3) infections, sepsis with pyothorax (1) and purulent meningitis (1). ASPC was effective in all but 1 case of pneumonia due to beta-lactamase-positive H. influenzae (effective rate; 96.7%). Adverse reactions and abnormalities of the laboratory tests were not associated with the ASPC therapy in any of the cases. The serum half-life of ASPC after an intravenous bolus injection was 0.883 +/- 0.194 hour and excretion into urine was rapid. From the present results, ASPC is a safe and effective antibiotic when used in patients with susceptible bacterial infections.

• Authors: B Kim, H Meguro, J Mashiko, H Yonezawa, T Kawaoi, T Tajima, R Fujii
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 38 Issue 7 Pg. 1835-45 (Jul 1985) ISSN: 0368-2781 [Print] Japan
• PMID: 4068222 (Publication Type: English Abstract, Journal Article)

Chemical References

• aspoxicillin
• Amoxicillin

Topics

• Adolescent
• Amoxicillin (adverse effects, analogs & derivatives, metabolism, therapeutic use)
• Bacteria (isolation & purification)
• Bacterial Infections (drug therapy, microbiology)
• Child
• Child, Preschool
• Drug Evaluation
• Female
• Humans
• Infant
• Male