Mitogenic effect in mouse liver induced by a hypolipidemic drug, nafenopin.

Abstract

The mitogenic effect of Nafenopin, a hypolipidemic hepatic peroxisome proliferator, in mouse liver has been studied in acute and chronically treated mice. After 1, 6 and 32 weeks of treatment, the total hepatic DNA was increased 1.5-2.0-fold over controls. Mitotic and labeling indices were also increased 3-4 fold after 5 days, 6 weeks and 32 weeks of treatment. The increased mitotic activity in nafenopin fed animals was not associated with liver cell necrosis. The nafenopin induced hepatomegaly therefore appears to arise from a combination of cell proliferation, as well as, cellular hypertrophy, which is associated with peroxisome proliferation.

• Authors: D E Moody, M S Rao, J K Reddy
• Journal: Virchows Archiv. B, Cell pathology (Virchows Arch B Cell Pathol) Vol. 23 Issue 4 Pg. 291-6 (Apr 15 1977) Germany
• PMID: 404752 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Mitogens
• Propionates
• Nafenopin

Topics

• Animals
• Hyperplasia
• Hypertrophy
• Liver (drug effects, ultrastructure)
• Male
• Mice
• Mice, Inbred Strains
• Microbodies (drug effects)
• Mitogens
• Nafenopin (pharmacology)
• Propionates (pharmacology)