Comparison of liver tumor frequencies after intermittent oral administration of different doses of N-nitrosopyrrolidine in Sprague-Dawley rats.

Abstract

N-Nitrosopyrrolidine (N-Pyr) was administered orally to 400 Sprague-Dawley rats. An additional group of 80 rats served as an untreated control. There were 5 individual groups in which the effects of different periods of dosing and varying intervals without treatment were compared. Individual doses corresponded to 0.0, 1.0, 1.2 and 2.0 mg/kg per day. The total dose (600 days after the start of the trial) always amounted to 600 mg/kg N-Pyr. Significantly different incidences of liver tumors were observed in the individual N-Pyr-treated groups. The findings support the assumption that tumor risks not only depend on individual and total doses of the administered carcinogen, but are also an age-related function.

• Authors: A Hoos, M Habs, D Schmähl
• Journal: Cancer letters (Cancer Lett) Vol. 26 Issue 1 Pg. 77-82 (Feb 1985) ISSN: 0304-3835 [Print] Ireland
• PMID: 3971355 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Nitrosamines
• N-Nitrosopyrrolidine

Topics

• Administration, Oral
• Age Factors
• Animals
• Liver Neoplasms, Experimental (chemically induced)
• Male
• N-Nitrosopyrrolidine (toxicity)
• Nitrosamines (toxicity)
• Rats
• Rats, Inbred Strains
• Risk