Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.

Abstract	Four histamine antagonists, methapyrilene, thenyldiamine, mepyramine and pyribenzamine were tested for carcinogenicity in rats by continuous application in drinking water. Only methapyrilene displayed significant carcinogenic effects, inducing liver tumors in a dose-related pattern. Analogues not containing a thiophene ring (mepyramine, pyribenzamine) did not exhibit neoplastic effects under the experimental conditions.
Authors	M Habs, P Shubik, G Eisenbrand
Journal	Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 111 Issue 1 Pg. 71-4 ( 1986) ISSN: 0171-5216 [Print] Germany
PMID	3949852 (Publication Type: Journal Article)
Chemical References	Aminopyridines Pyridines Tripelennamine Methapyrilene thenyldiamine Pyrilamine
Topics	Adenoma (chemically induced) Adrenal Gland Neoplasms (chemically induced) Aminopyridines Animals Dose-Response Relationship, Drug Female Liver Neoplasms (chemically induced) Liver Neoplasms, Experimental (chemically induced) Male Methapyrilene Neoplasms, Experimental (chemically induced) Pyridines Pyrilamine Rats Structure-Activity Relationship Tripelennamine

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