Bioavailability of warfarin in a patient with severe short bowel syndrome.

Abstract

Acquired warfarin resistance has resulted from altered drug metabolism and excessive vitamin K. A third possible mechanism, decreased gastrointestinal absorption of the drug, was examined in a patient with short bowel syndrome and severe malabsorption who demonstrated transient warfarin resistance. Despite the resistance, bioavailability studies demonstrated normal drug absorption and a prolonged half-life. The parenteral administration of vitamin K proved to be the cause of the prolonged warfarin resistance.

• Authors: P J Kearns Jr, R A O'Reilly
• Journal: JPEN. Journal of parenteral and enteral nutrition (JPEN J Parenter Enteral Nutr) 1986 Jan-Feb Vol. 10 Issue 1 Pg. 100-1 ISSN: 0148-6071 [Print] United States
• PMID: 3945042 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vitamin K
• Warfarin

Topics

• Adult
• Biological Availability
• Drug Resistance
• Female
• Half-Life
• Humans
• Injections, Subcutaneous
• Intestinal Absorption
• Malabsorption Syndromes (metabolism)
• Short Bowel Syndrome (metabolism)
• Vitamin K (administration & dosage)
• Warfarin (metabolism)