Treatment of allergic rhinitis with a new selective H1 antihistamine: terfenadine.

Abstract

The effectiveness of 60 mg b.i.d. of a novel antihistamine, terfenadine, was compared with an active control, 4 mg t.i.d. of chlorpheniramine, and placebo in 560 patients with seasonal allergic rhinitis. In contrast to the gradual decrease in seasonal symptoms observed over a 7 day period of study in placebo-treated patients, both antihistamines produced a prompt significant decrease in sneezing and rhinorrhea, and a gradual decrease in nasopharyngeal pruritus. Terfenadine-related sedation did not differ from that produced by the placebo and was less than the sedation produced by the active control.

• Authors: C E Buckley 3rd, S J Klemawesch, S K Lucas
• Journal: New England and regional allergy proceedings (N Engl Reg Allergy Proc) Vol. 6 Issue 1 Pg. 63-70 ( 1985) ISSN: 0742-2814 [Print] United States
• PMID: 3939672 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzhydryl Compounds
• Chlorpheniramine
• Terfenadine

Topics

• Administration, Oral
• Adult
• Benzhydryl Compounds (adverse effects, therapeutic use)
• Chlorpheniramine (adverse effects, therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Humans
• Male
• Random Allocation
• Rhinitis, Allergic, Seasonal (drug therapy)
• Sleep (drug effects)
• Terfenadine