Ovulation induction in polycystic ovary syndrome with urinary follicle-stimulating hormone or human menopausal gonadotropin.

Abstract

In patients with polycystic ovarian disease (PCOD) ovulation was induced with a combination of human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG) or with urinary follicle-stimulating hormone (uFSH; Metrodin, Serono Laboratories, Inc., Randolph, MA) alone. hMG/hCG and uFSH resulted in comparable rates of ovulation and conception in patients with PCOD. The incidence of hyperstimulation and the potential for multiple births appeared lower with uFSH. The fact that endogenous ovulation did not occur in hMG patients who had hCG withheld or in 3 of the 11 uFSH patients who had preovulatory levels of estradiol and follicles greater than 15 mm may imply that these similarly derived gonadotropins in some instances block endogenous ovulation.

• Authors: M M Seibel, C McArdle, D Smith, M L Taymor
• Journal: Fertility and sterility (Fertil Steril) Vol. 43 Issue 5 Pg. 703-8 (May 1985) ISSN: 0015-0282 [Print] United States
• PMID: 3922800 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chorionic Gonadotropin
• Estrone
• Testosterone
• Androstenedione
• Estradiol
• Menotropins
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Androstenedione (blood)
• Chorionic Gonadotropin (blood)
• Estradiol (blood)
• Estrone (blood)
• Female
• Follicle Stimulating Hormone (therapeutic use)
• Humans
• Luteinizing Hormone (blood)
• Menotropins (therapeutic use)
• Menstrual Cycle
• Ovulation Induction (methods)
• Polycystic Ovary Syndrome (physiopathology)
• Testosterone (blood)