Abstract |
A prospective, double-blind, placebo-controlled study was performed to determine the effectiveness of single-dose antibiotic prophylaxis in decreasing infectious complications after primary cesarean section. One hundred women at high risk for postoperative infectious morbidity were randomly assigned to receive either placebo or one 2-g dose of ceftizoxime at cord clamping. The incidence of endometritis in the antibiotic group was 6.0 versus 24.5% in the placebo group (P less than .05). The incidence of febrile morbidity in the group receiving one dose of ceftizoxime was 14.0 versus 32.7% in the placebo group (P less than .05). Single-dose ceftizoxime prophylaxis significantly reduced the incidence of endometritis and febrile morbidity in high-risk patients undergoing cesarean section.
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Authors | D H Saltzman, L J Eron, H H Kay, J G Sites |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 65
Issue 5
Pg. 655-7
(May 1985)
ISSN: 0029-7844 [Print] United States |
PMID | 3885107
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Ceftizoxime
- Cefotaxime
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Topics |
- Adult
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Cefotaxime
(administration & dosage, analogs & derivatives, therapeutic use)
- Ceftizoxime
- Cesarean Section
- Clinical Trials as Topic
- Double-Blind Method
- Female
- Humans
- Postoperative Complications
(prevention & control)
- Pregnancy
- Premedication
- Puerperal Infection
(prevention & control)
- Risk
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