Cross-Sectional and Prospective Association of Serum 25-Hydroxyvitamin D with Gut Mycobiota during Pregnancy among Women with Gestational Diabetes.

Abstract

SCOPE:

Little is known about the effect of blood vitamin D status on the gut mycobiota (i.e., fungi), a crucial component of the gut microbial ecosystem. The study aims to explore the association between 25-hydroxyvitamin D [25(OH)D] and gut mycobiota and to investigate the link between the identified mycobial features and blood glycemic traits.

METHODS AND RESULTS:

The study examines the association between serum 25(OH)D levels and the gut mycobiota in the Westlake Precision Birth Cohort, which includes pregnant women with gestational diabetes mellitus (GDM). The study develops a genetic risk score (GRS) for 25(OH)D to validate the observational results. In both the prospective and cross-sectional analyses, the vitamin D is associated with gut mycobiota diversity. Specifically, the abundance of Saccharomyces is significantly lower in the vitamin D-sufficient group than in the vitamin D-deficient group. The GRS of 25(OH)D is inversely associated with the abundance of Saccharomyces. Moreover, the Saccharomyces is positively associated with blood glucose levels.

CONCLUSION:

Blood vitamin D status is associated with the diversity and composition of gut mycobiota in women with GDM, which may provide new insights into the mechanistic understanding of the relationship between vitamin D levels and metabolic health.

• Authors: Yuhui Liang, Zengliang Jiang, Yuanqing Fu, Sha Lu, Zelei Miao, Menglei Shuai, Xinxiu Liang, Wanglong Gou, Ke Zhang, Rui-Qi Shi, Chang Gao, Mei-Qi Shi, Xu-Hong Wang, Wen-Sheng Hu, Ju-Sheng Zheng
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Pg. e2400022 (May 19 2024) ISSN: 1613-4133 [Electronic] Germany
• PMID: 38763911 (Publication Type: Journal Article)
• Copyright: © 2024 The Authors. Molecular Nutrition & Food Research published by Wiley‐VCH GmbH.