Emerging targets in lipid metabolism for cancer therapy.

Abstract

Cancer cells perturb lipid metabolic pathways for a variety of pro-tumorigenic functions, and deregulated cellular metabolism is a hallmark of cancer cells. Although alterations in lipid metabolism in cancer cells have been appreciated for over 20 years, there are no FDA-approved cancer treatments that target lipid-related pathways. Recent advances pertaining to cancer cell fatty acid synthesis (FAS), desaturation, and uptake, microenvironmental and dietary lipids, and lipid metabolism of tumor-infiltrating immune cells have illuminated promising clinical applications for targeting lipid metabolism. This review highlights emerging pathways and targets for tumor lipid metabolism that may soon impact clinical treatment.

• Authors: Alexander R Terry, Nissim Hay
• Journal: Trends in pharmacological sciences (Trends Pharmacol Sci) (May 17 2024) ISSN: 1873-3735 [Electronic] England
• PMID: 38762377 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.