Setup of Aerosol Delivery System to Prevent Measles Virus Infection in Nonhuman Primate Model.

Abstract

Measles virus is one of the most contagious airborne human viruses which keeps causing outbreaks in numerous countries over the world despite the existence of an efficient vaccine. Fusion inhibitory lipopeptides were shown to inhibit viral entry into target cells, and their adequate administration into the respiratory tract may provide a novel preventive approach against airborne infections. Aerosol delivery presents the best administration route to deliver such preventive compounds to the upper and lower respiratory tract. This approach offers a conceptually new strategy to protect the population at risk against infection by respiratory viruses, including measles. It is a noninvasive needle-free approach, which may be used when antiviral protection is required, without any medical assistance. In this chapter, we describe the nebulization approach of lipopeptide compounds in nonhuman primates and the subsequent measles virus challenge.

• Authors: Olivier Reynard, Jérôme Montharu, Mathieu Iampietro, Claudia Gonzalez, Sandrine Le Guellec, Branka Horvat, Laurent Vecellio
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 2808 Pg. 167-175 ( 2024) ISSN: 1940-6029 [Electronic] United States
• PMID: 38743370 (Publication Type: Journal Article)
• Copyright: © 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Topics

• Animals
• Measles (prevention & control)
• Measles virus
• Aerosols
• Disease Models, Animal
• Lipopeptides (administration & dosage)
• Humans
• Drug Delivery Systems (methods)