Abstract |
Glioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional data analysis and experimental validation, we investigated the genetic landscape of SLCs in glioma. We established a classification system comprising 7-SLCs to predict the prognosis of glioma patients and their potential responses to immunotherapy and chemotherapy. Our findings unveiled specific SLC expression patterns and their correlation with the immune-suppressive microenvironment and metabolic status. The 7-SLC classification system was validated in distinguishing subgroups within the microenvironment, specifically identifying subsets involving malignant cells and tumour-associated macrophages. Furthermore, the orphan protein SLC43A3, a core member of the 7-SLC classification system, was identified as a key facilitator of tumour cell proliferation and migration, suggesting its potential as a novel target for cancer therapy.
|
Authors | Wenjie Wu, Cheng Jiang, Wende Zhu, Xiaobing Jiang |
Journal | Journal of cellular and molecular medicine
(J Cell Mol Med)
Vol. 28
Issue 9
Pg. e18339
(May 2024)
ISSN: 1582-4934 [Electronic] England |
PMID | 38687049
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2024 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. |
Chemical References |
- Solute Carrier Proteins
- Biomarkers, Tumor
|
Topics |
- Tumor Microenvironment
(immunology, genetics)
- Humans
- Glioma
(genetics, immunology, pathology, metabolism)
- Gene Expression Regulation, Neoplastic
- Brain Neoplasms
(genetics, immunology, pathology, metabolism)
- Solute Carrier Proteins
(genetics, metabolism)
- Prognosis
- Cell Proliferation
(genetics)
- Gene Expression Profiling
- Biomarkers, Tumor
(genetics, metabolism)
- Cell Line, Tumor
- Multiomics
|