CD300e: Emerging role and mechanism as an immune-activating receptor.

Abstract

As a transmembrane protein, CD300e is primarily expressed in myeloid cells. It belongs to the CD300 glycoprotein family, functioning as an immune-activating receptor. Dysfunction of CD300e has been suggested in many diseases, such as infections, immune disorders, obesity, and diabetes, signifying its potential as a key biomarker for disease diagnosis and treatment. This review is aimed to explore the roles and potential mechanisms of CD300e in regulating oxidative stress, immune cell activation, tissue damage and repair, and lipid metabolism, shedding light on its role as a diagnostic marker or a therapeutic target, particularly for infections and autoimmune disorders.

• Authors: Na Liu, Wenchang Sun, Weixing Gao, Shushan Yan, Chunjuan Yang, Jin Zhang, Biao Ni, Lili Zhang, Jie Zang, Sue Zhang, Donghua Xu
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 133 Pg. 112055 (May 30 2024) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 38677094 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2024. Published by Elsevier B.V.

Chemical References

• Receptors, Immunologic
• Antigens, CD
• Biomarkers

Topics

• Humans
• Animals
• Receptors, Immunologic (metabolism, immunology)
• Oxidative Stress
• Lipid Metabolism
• Autoimmune Diseases (immunology)
• Antigens, CD (metabolism, immunology)
• Biomarkers