MAFLD with central obesity is associated with increased risk of colorectal adenoma and high-risk adenoma.

Abstract

OBJECTIVE:

To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma.

METHODS:

A total of 1395 subjects were enrolled and divided into a colorectal adenoma group (593 subjects) and a control group (802 subjects) according to the inclusion and exclusion criteria. The characteristics of patients in the colorectal adenoma group and the control group were compared by the chi-square test. Univariate and multivariate logistic analyses were used to analyze independent risk factors and associations with different MAFLD subtypes. Colorectal adenoma characteristics and the proportion of patients with high-risk colorectal adenoma were also compared.

RESULTS:

High-density lipoprotein (HDL-C) was significantly lower in patients in the colorectal adenoma group than in those in the control group (P < 0.001). Logistic regression analysis revealed that age, obesity status, central obesity status, hypertension status, diabetes status, fatty liver status, smoking history, BMI, waist circumference, triglyceride level, HDL-C level, fasting blood glucose level and degree of hepatic steatosis were all independent risk factors for colorectal adenoma. Notably, MAFLD was associated with a significantly increased risk of colorectal adenoma in patients with central obesity (P < 0.001). In addition, obesity, central obesity, diabetes, fatty liver and degree of hepatic steatosis were all shown to be independent risk factors for high-risk colorectal adenoma. In addition, a greater proportion of MAFLD patients with central obesity than those without central obesity had high-risk colorectal adenoma.

CONCLUSION:

MAFLD and central obesity are independently associated with the development of colorectal adenoma. MAFLD with central obesity is associated with an increased risk of colorectal adenoma and high-risk adenoma.

• Authors: Jingfang Xiong, Yijun Wu, Dongya Chen, Zhaolin Zhang, Yihui Liu, Jiandong Luo, Hong Xu
• Journal: BMC gastroenterology (BMC Gastroenterol) Vol. 24 Issue 1 Pg. 138 (Apr 22 2024) ISSN: 1471-230X [Electronic] England
• PMID: 38649845 (Publication Type: Journal Article)
• Copyright: © 2024. The Author(s).

Topics

• Humans
• Male
• Colorectal Neoplasms (etiology, epidemiology)
• Female
• Adenoma (epidemiology)
• Middle Aged
• Obesity, Abdominal (complications, epidemiology)
• Risk Factors
• Aged
• Fatty Liver (complications, epidemiology)
• Adult
• Logistic Models
• Case-Control Studies
• Waist Circumference