Comparison of outcomes and characteristics of patients admitted to the ICU with COVID-19 and other community-acquired pneumonia based on propensity score matching.

Abstract

OBJECTIVE:

To compare the similarities and differences between patients with Coronavirus Disease 2019 (COVID-19) and those with other community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU), utilizing propensity score matching (PSM), regarding hospitalization expenses, treatment options, and prognostic outcomes, aiming to inform the diagnosis and treatment of COVID-19.

METHODS:

Patients admitted to the ICU of the Third People's Hospital of Datong City, diagnosed with COVID-19 from December 2022 to February 2023, constituted the observation group, while those with other CAP admitted from January to November 2022 formed the control group. Basic information, clinical data at admission, and time from symptom onset to admission were matched using PSM.

RESULTS:

A total of 70 patients were included in the COVID-19 group and 119 in the CAP group. The patients were matched by the propensity matching method, and 37 patients were included in each of the last two groups. After matching, COVID-19 had a higher failure rate than CAP, but the difference was not statistically significant (73% vs. 51%, p = 0.055). The utilization rate of antiviral drugs (40% vs. 11%, p = 0.003), γ-globulin (19% vs. 0%, p = 0.011) and prone position ventilation (PPV) (27% vs. 0%, p < 0.001) in patients with COVID-19 were higher than those in the CAP, and the differences were statistically significant. The total hospitalization cost of COVID-19 patients was lower than that of CAP patients, and the difference was statistically significant (27889.5 vs. 50175.9, p = 0.007). The hospital stay for COVID-19 patients was shorter than for CAP patients, but the difference was not statistically significant (10.9 vs. 16.6, p = 0.071).

CONCLUSION:

Our findings suggest that limited medical resources influenced patient outcomes during the COVID-19 pandemic. Addressing substantial demands for ICU capacity and medications during this period could have potentially reduced the mortality rate among COVID-19 patients.

• Authors: Hongli Zhao, Xiulin Yan, Ziru Guo, Kaiyu Li, Zhaopeng Wang, Jun Wang, Dong Lv, Jianling Zhu, Ye Chen
• Journal: BMC infectious diseases (BMC Infect Dis) Vol. 24 Issue 1 Pg. 419 (Apr 22 2024) ISSN: 1471-2334 [Electronic] England
• PMID: 38644489 (Publication Type: Journal Article, Comparative Study, Research Support, Non-U.S. Gov't)
• Copyright: © 2024. The Author(s).

Chemical References

• Antiviral Agents

Topics

• Humans
• COVID-19 (mortality, therapy, epidemiology)
• Male
• Female
• Propensity Score
• Community-Acquired Infections (mortality, therapy, epidemiology)
• Middle Aged
• Intensive Care Units (statistics & numerical data)
• Aged
• SARS-CoV-2
• Hospitalization (statistics & numerical data)
• China (epidemiology)
• Retrospective Studies
• Antiviral Agents (therapeutic use)
• Length of Stay (statistics & numerical data)
• Adult
• Treatment Outcome
• Prognosis
• Pneumonia (mortality, therapy)