The STRAT-PARK cohort: A personalized initiative to stratify Parkinson's disease.
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| Abstract |
The STRAT-PARK initiative aims to provide a platform for stratifying Parkinson's disease (PD) into biological subtypes, using a bottom-up, multidisciplinary biomarker-based and data-driven approach. PD is a heterogeneous entity, exhibiting high interindividual clinicopathological variability. This diversity suggests that PD may encompass multiple distinct biological entities, each driven by different molecular mechanisms. Molecular stratification and identification of disease subtypes is therefore a key priority for understanding and treating PD. STRAT-PARK is a multi-center longitudinal cohort aiming to recruit a total of 2000 individuals with PD and neurologically healthy controls from Norway and Canada, for the purpose of identifying molecular disease subtypes. Clinical assessment is performed annually, whereas biosampling, imaging, and digital and neurophysiological phenotyping occur every second year. The unique feature of STRAT-PARK is the diversity of collected biological material, including muscle biopsies and platelets, tissues particularly useful for mitochondrial biomarker research. Recruitment rate is ∼150 participants per year. By March 2023, 252 participants were included, comprising 204 cases and 48 controls. STRAT-PARK is a powerful stratification initiative anticipated to become a global research resource, contributing to personalized care in PD.
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| Authors | Kjersti Eline Stige, Simon Ulvenes Kverneng, Soumya Sharma, Geir-Olve Skeie, Erika Sheard, Mona Søgnen, Solveig Af Geijerstam, Therese Vetås, Anne Grete Wahlvåg, Haakon Berven, Sagar Buch, David Reese, Dina Babiker, Yekta Mahdi, Trevor Wade, Gala Prado Miranda, Jacky Ganguly, Yokhesh Krishnasamy Tamilselvam, Jia Ren Chai, Saurabh Bansal, Dorian Aur, Sima Soltani, Scott Adams, Christian Dölle, Fiona Dick, Erik Magnus Berntsen, Renate Grüner, Njål Brekke, Frank Riemer, Pål Erik Goa, Kristoffer Haugarvoll, E Mark Haacke, Mandar Jog, Charalampos Tzoulis |
| Journal | Progress in neurobiology (Prog Neurobiol) Vol. 236 Pg. 102603 (May 2024) ISSN: 1873-5118 [Electronic] England |
| PMID | 38604582 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study, Review) |
| Copyright | Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. |
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