Adipose tissue is the first and primary target organ of
obesity and the main source of circulating
miRNAs in patients with
obesity. This systematic review aimed to analyze and summarize the generation and mechanisms of adipose-derived
miRNAs and their role as early predictors of various
obesity-related complications. Literature searches in the PubMed and Web of Science databases using terms related to
miRNAs,
obesity, and adipose tissue. Pre-
miRNAs from the Human
MicroRNA Disease Database, known to regulate
obesity-related metabolic disorders, were combined for intersection processing. Validated
miRNA targets were sorted through literature review, and enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes via the KOBAS online tool, disease analysis, and
miRNA transcription factor prediction using the TransmiR v. 2.0 database were also performed. Thirty
miRNAs were identified using both
obesity and adipose secretion as criteria. Seventy-nine functionally validated targets associated with 30 comorbidities of these
miRNAs were identified, implicating pathways such as autophagy, p53 pathways, and
inflammation. The
miRNA precursors were analyzed to predict their
transcription factors and explore their biosynthesis mechanisms. Our findings offer potential insights into the epigenetic changes related to adipose-driven
obesity-related comorbidities.