Abstract | BACKGROUND: To date, evidence has been lacking regarding bevacizumab pharmacokinetics in the cerebrospinal fluid (CSF). OBJECTIVE: This study assessed the penetration of bevacizumab, as part of a metronomic antiangiogenic treatment regimen, into the CSF of children, adolescents, and young adults with recurrent brain tumors. PATIENTS AND METHODS: RESULTS: Apart from in serum (minimum concentration/maximum concentration [Cmin/Cmax] 77.0-305/267-612 mg/L, median 144/417 mg/L), bevacizumab could be quantified in the CSF (0.01-2.26 mg/L, median 0.35 mg/L). The CSF/serum ratio was 0.16 and highly variable between patients. Malignant cells could be detected in CSF before initiation of treatment in five of 12 patients; after treatment, the CSF was cleared in all patients. VEGF-A was detected in three patients before treatment (mean ± SD: 20 ± 11 pg/mL), and was still measurable in one of these patients despite treatment (16 pg/mL). CONCLUSIONS: This pharmacokinetic pilot study indicated penetration of bevacizumab into the CSF in a population of children, adolescents, and young adults with recurrent brain tumors.
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Authors | Iris K Minichmayr, Ursula Knaack, Johannes Gojo, Daniel Senfter, Christine Haberler, Amedeo A Azizi, Lisa Mayr, Markus Zeitlinger, Andreas Peyrl |
Journal | Paediatric drugs
(Paediatr Drugs)
(Apr 08 2024)
ISSN: 1179-2019 [Electronic] Switzerland |
PMID | 38587585
(Publication Type: Journal Article)
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Copyright | © 2024. The Author(s). |