Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis.

Abstract

One new highly degraded steroid, namely 21-nor-4-ene-chaxine A (1) furnishing a 5/6/5-tricyclic, along with one known related analogue (2), were isolated from the South China Sea sponge Spongia officinalis. Their structures including absolute configurations were established by extensive spectroscopic data analysis, TDDFT-ECD calculation, and comparison with the spectral data previously reported in the literature. Compound 1 represent the new member of incisterols family with a highly degradation in ring B. In vitro bioassays revealed compound 2 exhibited significant anti-microglial inflammatory effect on lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells.

• Authors: Jiao Liu, Zi-Yi Liu, Yan Fu, Yu-Cheng Gu, Song-Wei Li, Hai-Yan Zhang, Yue-Wei Guo
• Journal: Chemistry & biodiversity (Chem Biodivers) Pg. e202400519 (Apr 04 2024) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 38576052 (Publication Type: Journal Article)
• Copyright: © 2024 Wiley-VHCA AG, Zurich, Switzerland.