Adoptive immunotherapy in the T cell landscape exhibits efficacy in
cancer treatment. Over the past few decades, genetically modified T cells, particularly
chimeric antigen receptor T cells, have enabled remarkable strides in the treatment of
hematological malignancies. Besides, extensive exploration of multiple
antigens for the treatment of solid
tumors has led to clinical interest in the potential of T cells expressing the engineered
T cell receptor (TCR). TCR-T cells possess the capacity to recognize intracellular
antigen families and maintain the intrinsic properties of TCRs in terms of affinity to target
epitopes and signal transduction. Recent research has provided critical insight into their capability and therapeutic targets for multiple refractory solid
tumors, but also exposes some challenges for durable efficacy. In this review, we describe the screening and identification of available tumor antigens, and the acquisition and optimization of TCRs for TCR-T cell
therapy. Furthermore, we summarize the complete flow from laboratory to clinical applications of TCR-T cells. Last, we emerge future prospects for improving therapeutic efficacy in
cancer world with combination
therapies or TCR-T derived products. In conclusion, this review depicts our current understanding of TCR-T cell
therapy in solid
neoplasms, and provides new perspectives for expanding its clinical applications and improving therapeutic efficacy.