Association of exposure to phthalates and phthalate alternatives with dyslexia in Chinese primary school children.

Abstract

Previous studies have shown associations between children's exposure to phthalates and neurodevelopmental disorders. Whereas the impact of exposure to phthalate alternatives is understudied. This study aimed to evaluate the association of exposure to phthalates/their alternatives with the risk of dyslexia. We recruited 745 children (355 dyslexia and 390 non-dyslexia) via the Tongji Reading Environment and Dyslexia Research Project, and their urine samples were collected. A total of 26 metabolites of phthalates/their alternatives were measured. Multivariate logistic regression and quantile-based g-computation were used to estimate the associations of exposure to the phthalates/their alternatives with dyslexia. More than 80% of the children had 17 related metabolites detected in their urine samples. After adjustment, the association between mono-2-(propyl-6-hydroxy-heptyl) phthalate (OH-MPHP) with the risk of dyslexia was observed. Compared with the lowest quartile of OH-MPHP levels, the odds of dyslexia for the third quartile was 1.93 (95% CI 1.06, 3.57). Regarding mixture analyses, it was found that OH-MPHP contributed the most to the association. Further analyses stratified by sex revealed that this association was only observed in boys. Our results suggested a significantly adverse association of di-2-propylheptyl phthalate exposure with children's language abilities. It highlights the necessity to prioritize the protection of children's neurodevelopment by minimizing their exposure to endocrine-disrupting chemicals like di-2-propylheptyl phthalate.

• Authors: Qi Jiang, Yanjian Wan, Kaiheng Zhu, Haoxue Wang, Yanan Feng, Zhen Xiang, Rundong Liu, Shuai Zhao, Ying Zhu, Ranran Song
• Journal: Environmental science and pollution research international (Environ Sci Pollut Res Int) Vol. 31 Issue 19 Pg. 28392-28403 (Apr 2024) ISSN: 1614-7499 [Electronic] Germany
• PMID: 38538993 (Publication Type: Journal Article)
• Copyright: © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Phthalic Acids
• Environmental Pollutants
• phthalic acid

Topics

• Humans
• Phthalic Acids (urine)
• Child
• Male
• Female
• Environmental Exposure
• Dyslexia (chemically induced)
• China
• Environmental Pollutants (urine)
• Schools
• East Asian People