Nutrition and Cardiovascular Disease: The Potential Role of Marine Bioactive Proteins and Peptides in Thrombosis Prevention.

Abstract

Thrombus and cardiovascular diseases pose a significant health threat, and dietary interventions have shown promising potential in reducing the incidence of these diseases. Marine bioactive proteins and peptides have been extensively studied for their antithrombotic properties. They can inhibit platelet activation and aggregation by binding to key receptors on the platelet surface. Additionally, they can competitively anchor to critical enzyme sites, leading to the inhibition of coagulation factors. Marine microorganisms also offer alternative sources for the development of novel fibrinolytic proteins, which can help dissolve blood clots. The advancements in technologies, such as targeted hydrolysis, specific purification, and encapsulation, have provided a solid foundation for the industrialization of bioactive peptides. These techniques enable precise control over the production and delivery of bioactive peptides, enhancing their efficacy and safety. However, it is important to note that further research and clinical studies are needed to fully understand the mechanisms of action and therapeutic potential of marine bioactive proteins and peptides in mitigating thrombotic events. The challenges and future application perspectives of these bioactive peptides also need to be explored.

• Authors: Shuzhen Cheng, Lushun Yuan, Ruifang Li-Gao, Siru Chen, Han Li, Ming Du
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 72 Issue 13 Pg. 6815-6832 (Apr 03 2024) ISSN: 1520-5118 [Electronic] United States
• PMID: 38523314 (Publication Type: Journal Article, Review)

Chemical References

• Peptides
• Anticoagulants

Topics

• Humans
• Cardiovascular Diseases (prevention & control)
• Peptides (pharmacology, chemistry)
• Anticoagulants (chemistry)
• Blood Platelets
• Thrombosis (prevention & control, drug therapy)