Abstract |
The exact pathogenesis of IgA nephropathy (IgAN) is complex and so far, not well defined. Since it has been shown that microbial infections could induce high levels of type I interferon (IFN-I) and there is an evident link between mucosal infection and gross hematuria in IgAN, we hypothesized that IFN-I may play a role in the pathogenic process. In this study, we investigated the type I interferon status in IgAN based on the expression of 17 IFN-regulated genes (IRGs) in whole blood from 59 IgAN patients in a cross-sectional study, of which 34 patients followed longitudinally. Analysis of the IFN-score showed that there was a significant elevated IFN-score in the IgAN patients compared with healthy controls (n = 28, p = 9.80 × 10-3), and we observed an elevated IFN-score in the group with less tubular atrophy/interstitial fibrosis (p = 1.07 × 10-2) and with a lower proportion of mesangial hypercellularity (p = 1.23 × 10-2). In the longitudinal analysis, Cox regression analysis revealed that a higher IFN level was associated with a better renal outcome in IgAN after adjustments for gender and age (hazard ratio, 0.90; 95 % confidence interval, 0.81 to 0.97; p = 4.20 × 10-2). In conclusion, our finding suggested that IFN score may represent a novel type of biomarker in IgAN, which requires further exploration on its mechanism and therapeutic targeting.
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Authors | Shu Qu, Ting Gan, Yan-Na Wang, Yuan-Yuan Qi, Yue-Miao Zhang, Celine C Berthier, Li-Jun Liu, Su-Fang Shi, Ji-Cheng Lv, Hong Zhang, Xu-Jie Zhou |
Journal | International immunopharmacology
(Int Immunopharmacol)
Vol. 131
Pg. 111920
(Apr 20 2024)
ISSN: 1878-1705 [Electronic] Netherlands |
PMID | 38522142
(Publication Type: Journal Article)
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Copyright | Copyright © 2024 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Humans
- Glomerulonephritis, IGA
(genetics, drug therapy)
- Interferon Type I
(genetics, therapeutic use)
- Cross-Sectional Studies
- Prognosis
- Kidney
(pathology)
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