Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus.

Abstract

Pathologic type I interferon (T1IFN) expression is a key feature in systemic lupus erythematosus (SLE) that associates with disease activity. When compared to adult-onset disease, juvenile-onset (j)SLE is characterized by increased disease activity and damage, which likely relates to increased genetic burden. To identify T1IFN-associated gene polymorphisms (TLR7, IRAK1, miR-3142/miR-146a, IRF5, IRF7, IFIH1, IRF8, TYK2, STAT4), identify long-range linkage disequilibrium and gene:gene interrelations, 319 jSLE patients were genotyped using panel sequencing. Coupling phenotypic quantitative trait loci (QTL) analysis identified 10 jSLE QTL that associated with young age at onset (<12 years; IRAK1 [rs1059702], TLR7 [rs3853839], IFIH1 [rs11891191, rs1990760, rs3747517], STAT4 [rs3021866], TYK2 [rs280501], IRF8 [rs1568391, rs6638]), global disease activity (SLEDAI-2 K >10; IFIH1 [rs1990760], STAT4 [rs3021866], IRF8 [rs903202, rs1568391, rs6638]), and mucocutaneous involvement (TLR7 [rs3853839], IFIH1 [rs11891191, rs1990760]). This study suggests T1IFN-associated polymorphisms and gene:gene interrelations in jSLE. Genotyping of jSLE patients may allow for individualized treatment and care.

• Authors: Yves Renaudineau, Amandine Charras, Valentina Natoli, Mathieu Fusaro, Eve M D Smith, Michael W Beresford, Christian M Hedrich, UK jSLE Cohort Study
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 262 Pg. 110194 (May 2024) ISSN: 1521-7035 [Electronic] United States
• PMID: 38508295 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Chemical References

• Interferon-Induced Helicase, IFIH1
• Interferon Type I
• Toll-Like Receptor 7
• Interferon Regulatory Factors
• MicroRNAs

Topics

• Adult
• Humans
• Child
• Interferon-Induced Helicase, IFIH1
• Interferon Type I (genetics)
• Epistasis, Genetic
• Toll-Like Receptor 7 (genetics)
• Lupus Erythematosus, Systemic (genetics, complications)
• Interferon Regulatory Factors (genetics)
• MicroRNAs