Nanomaterials Boost CAR-T Therapy for Solid Tumors.

Abstract

T cell engineering, particularly via chimeric antigen receptor (CAR) modifications for enhancing tumor specificity, has shown efficacy in treating hematologic malignancies. The extension of CAR-T cell therapy to solid tumors, however, is impeded by several challenges: the absence of tumor-specific antigens, antigen heterogeneity, a complex immunosuppressive tumor microenvironment, and physical barriers to cell infiltration. Additionally, limitations in CAR-T cell manufacturing capacity and the high costs associated with these therapies restrict their widespread application. The integration of nanomaterials into CAR-T cell production and application offers a promising avenue to mitigate these challenges. Utilizing nanomaterials in the production of CAR-T cells could decrease product variability and lower production expenses, positively impacting the targeting and persistence of CAR-T cells in treatment and minimizing adverse effects. This review comprehensively evaluates the use of various nanomaterials in the production of CAR-T cells, genetic modification, and in vivo delivery. It discusses their underlying mechanisms and potential for clinical application, with a focus on improving specificity and safety in CAR-T cell therapy. This article is protected by copyright. All rights reserved.

• Authors: Jun Long, Yian Wang, Xianjie Jiang, Junshang Ge, Mingfen Chen, Boshu Zheng, Rong Wang, Meifeng Wang, Meifang Xu, Qi Ke, Jie Wang
• Journal: Advanced healthcare materials (Adv Healthc Mater) Pg. e2304615 (Mar 14 2024) ISSN: 2192-2659 [Electronic] Germany
• PMID: 38483400 (Publication Type: Journal Article, Review)
• Copyright: This article is protected by copyright. All rights reserved.