Abstract |
Healthy alveolar bone is the cornerstone of oral function and oral treatment. Alveolar bone is highly dynamic during the entire lifespan and is affected by both systemic and local factors. Importantly, alveolar bone is subjected to unique occlusal force in daily life, and mechanical force is a powerful trigger of bone remodeling, but the effect of occlusal force in maintaining alveolar bone mass remains ambiguous. In this study, the Piezo1 channel is identified as an occlusal force sensor. Activation of Piezo1 rescues alveolar bone loss caused by a loss of occlusal force. Moreover, we identify Piezo1 as the mediator of occlusal force in osteoblasts, maintaining alveolar bone homeostasis by directly promoting osteogenesis and by sequentially regulating catabolic metabolism through Fas ligand (FasL)-induced osteoclastic apoptosis. Interestingly, Piezo1 activation also exhibits remarkable efficacy in the treatment of alveolar bone osteoporosis caused by estrogen deficiency, which is highly prevalent among middle-aged and elderly women. Promisingly, Piezo1 may serve not only as a treatment target for occlusal force loss-induced alveolar bone loss but also as a potential target for metabolic bone loss, especially in older patients.
|
Authors | Yiling Yang, Qinggang Dai, Xin Gao, Yanfei Zhu, Mi Ri Chung, Anting Jin, Yuanqi Liu, Xijun Wang, Xiangru Huang, Siyuan Sun, Hongyuan Xu, Jingyi Liu, Lingyong Jiang |
Journal | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
(J Bone Miner Res)
(Mar 03 2024)
ISSN: 1523-4681 [Electronic] England |
PMID | 38477783
(Publication Type: Journal Article)
|
Copyright | © The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. All rights reserved. For permissions, please email: [email protected]. |