Combined islet and kidney xenotransplantation for diabetic nephropathy: an update in ongoing research for a clinically relevant application of porcine islet transplantation.
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| Abstract |
Combined islet and kidney xenotransplantation for the treatment of diabetic nephropathy represents a compelling and increasingly relevant therapeutic possibility for an ever-growing number of patients who would benefit from both durable renal replacement and cure of the underlying cause of their renal insufficiency: diabetes. Here we briefly review immune barriers to islet transplantation, highlight preclinical progress in the field, and summarize our experience with combined islet and kidney xenotransplantation, including both challenges with islet-kidney composite grafts as well as our recent success with sequential kidney followed by islet xenotransplantation in a pig-to-baboon model.
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| Authors | Daniel L Eisenson, Hayato Iwase, Weili Chen, Yu Hisadome, Wanxing Cui, Michelle R Santillan, Alexander C Schulick, Du Gu, Amanda Maxwell, Kristy Koenig, Zhaoli Sun, Daniel Warren, Kazuhiko Yamada |
| Journal | Frontiers in immunology (Front Immunol) Vol. 15 Pg. 1351717 ( 2024) ISSN: 1664-3224 [Electronic] Switzerland |
| PMID | 38476227 (Publication Type: Journal Article, Review) |
| Copyright | Copyright © 2024 Eisenson, Iwase, Chen, Hisadome, Cui, Santillan, Schulick, Gu, Maxwell, Koenig, Sun, Warren and Yamada. |
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